This is the most common use case for the ISO today.
Here are the of the CodeBreaker version 10.1 for the PlayStation 2: Codebreaker 10.1 Iso Ps2l
: Unlike earlier versions that struggled with newer hardware, 10.1 is notably reliable on Emulation Ready This is the most common use case for the ISO today
: On emulators or modified hardware, the ISO allows users to select cheats and then "swap" to the game disc to apply the effects in real-time. Save File Management Codebreaker 10.1 Iso Ps2l