This is usually not a fault of the save file, but of the . Resident Evil 4 is notoriously picky about the console region. If you are playing the NTSC-U (North American) version of the ISO but your BIOS is PAL (European), or vice versa, the game may refuse to save or load.
If you are transferring saves from a PC emulator like PCSX2, ensure you are using the same "Memory Card" format. AetherSX2 is highly compatible with PCSX2 .ps2 card files. save data resident evil 4 aether sx2 full
CRC-32: A4F3C291 MD5: 8d22a3f1191b4d8f9c4b6a7e3d0c5b2f (Verify after download to avoid corrupted data.) This is usually not a fault of the save file, but of the